In the twentieth century, antibiotics were considered effective agents against bacteria-caused infectious diseases. Today, however, disease-causing microbes quickly develop resistance to these substances and sometimes even stop growing during the activity of drugs, then to restore the colony and re-run the disease. Recently, a group of scientists from the University of Surrey (England) found that some bacteria are able to literally forget how to grow, thereby ensuring survival during the murderous work of antibiotics. It begins this “forgetfulness” at the genetic level
About the new opening of scientists was described in a scientific journal PNAS. While studying a strain of E. coli (Escherichia coli), the researchers found that some of them have mutations in the gene ydcl, due to which bacteria like forget how to grow. Later they become small and slow, making the antibiotics simply can’t find it and destroy it. In fact, these bacteria become resistant to drugs and may eventually multiply to launch an infectious disease again. It turns out that now, in some cases, the human treatment with antibiotics is ineffective.
How to produce antibiotic resistance?
During the bacteria carefully hidden from the antibiotics they produce them even more stability. Now scientists know that pathogens are hiding from drugs due to changes in gene ydcl. It is likely that in the future will create technology that will allow microbes to hibernate. Ideally, because of this, it will be possible to thoroughly treat infectious diseases and prevent their reappearance in manifestation due to the suddenly “revived” bacteria.
The mortality rate in the world may increase
If scientists fail to do this then by the year 2050, mortality due to antibiotic-resistant bacteria can significantly increase. According to data from the world health organization, in 2016 in the world died 56,9 million people. In the future this number may increase as due to the high mortality from cardiovascular disease and cancer, and due to the fact that antibiotics will cease to be effective tools against serious diseases. At the moment, because of this, die each year 700 000 people, but after a few decades, this figure could reach 10 million people a year.
But resistance to antibiotics produce a very dangerous bacteria. For example, in 2019 in the African Republic of the Congo has been found a strain of bacteria of the genus Salmonella (Salmonella Typhimurium) who are not afraid none of the current drugs. Their stability is due to the fact that they have lost the necessary for the movement of flagella and become invisible to immune cells. Because of this, a lot of people now at risk of Contracting salmonellosis, whichtakes place after 2-7 days of high fever, vomiting and pain in the stomach, but still can be complicated and cause death.