Found a way to eliminate the double protection of bacteria from antibiotics

Since the opening in 1929 of antibiotics many years have passed, and during this time dangerous bacteria have learned to defend themselves from their main killers. They have developed protective mechanisms, and if scientists will find meaningful ways to avoid them, humanity can once again become vulnerable to a huge number of diseases. Some bacteria protection consists of two layers — the benefit, researchers from Thomas Jefferson University have found a way to destroy them at once.

Two layers of protection, for example, have E. coli and Salmonella. If the antibiotic and pass through one layer of the cell membrane, the second layer will push it back. However, there is one loophole — proteins, which are important for the functioning of the cells produced RNA, changing the structure of which it is possible to provoke errors.

To prove this, the researchers created engineering strains of Escherichia coli and Salmonella, depriving them of the RNA transport of a certain chemical parts. Having “defective” molecules, bacteria are unable to produce protective proteins, and their cell membranes had lost their cohesion. Therefore, they could pass more antibiotic molecules and bacteria died much faster.

We have proved that intervention in the molecule of transport RNA harms the ability of bacterial cells to produce membrane proteins required for protection against antibiotics. The rate of destruction of bacteria is extremely important — the longer the bacteria die, the more likely the development of resistance.

I-Ming HOU, head of the research group

Now before scientists there is a more ambitious target — they need to develop a way to change the structure of transport RNA. The bacteria used in the experiment were designed, but in nature they are still excellent produce protective proteins.

It is noteworthy that some bacteria for the salvation of the colony may even sacrifice themselves. How this happens, read our material.