In the brain open a physiological process that has searched for more than 100 years

The hallmark of some neurodegenerative diseases like the Huntington’s disease is the gradual death of nerve cells in the brain. Thus cells don’t die visapro. First, they start to “disconnect” from each other, and then breaking the links between them are progressing. During this process, because of which this occurs has remained unclear for more than 100 years since the first descriptions of the disease. And now the veil of secrecy was slightly opened.

The discovery managed to make scientists from the Medical school of the University of Pittsburgh. They are using animal models and lab-grown nerve cells, found out about the existence of a new physiological process called “negritos”.

 

“Neuritis is a process that has never been previously described and it can play a very important role in normal brain development, aging and neurodegenerative diseases.” said lead author Dr. Robert Friedlander.

It all started with the fact that one of the members of the laboratory of Dr. Friedlander Sergey Baranov noticed an interesting phenomenon in the nerve cells of the laboratory mouse.

“Their mitochondria are not working as they should on the periphery of the brain cells. Then when we looked at neurons in the spinal cord, we found the same phenomenon. Probably noticed it before, but we have identified the relationship.”

The researchers found that when the proteins in the mitochondria were damaged, and new proteins were not reported. This made them function less effective activated “enzyme death”, and ultimately caused the death of neurons. Scientists have suggested that neuritis is a variant of the apoptosis (programmed death process of cells).

The researchers then decided to see if neurites plays a role in the development of neurodegenerative diseases. Previous work in teams Dr. Friedlander showed that the Huntington’s disease impaired transport chain protein. Now they were able to confirm this guess.

“It is likely that neurites that begins in nerve cells and is considered the norm, with the physiological course does not lead to cell death. But at higher level of stress to already vulnerable cells may develop neurodegenerative lesions, which leads to the first violation of the ties, and then neuronal death. If we find a way to protect the mitochondria, we find the key to treating diseases.”